de Lau Lonneke M L, Koudstaal Peter J, van Meurs Joyce B J, Uitterlinden André G, Hofman Albert, Breteler Monique M B
Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
Ann Neurol. 2005 Jun;57(6):927-30. doi: 10.1002/ana.20509.
In a prospective, population-based cohort study among 5,920 participants aged 55 years or older, we observed that the TT variant of the methylenetetrahydrofolate reductase C677T polymorphism is associated with an increased risk for Parkinson's disease in smokers. Both smoking and the TT genotype are known to induce hyperhomocystinemia, and synergistic effects on homocysteine levels have been reported. Increased plasma levels of homocysteine through direct neurotoxic effects might accelerate the selective dopaminergic cell death underlying Parkinson's disease. Our findings support the hypothesis that homocysteine plays a role in the pathogenesis of Parkinson's disease.
在一项针对5920名55岁及以上参与者的基于人群的前瞻性队列研究中，我们观察到，亚甲基四氢叶酸还原酶C677T多态性的TT变异体与吸烟者患帕金森病的风险增加有关。已知吸烟和TT基因型都会诱发高同型半胱氨酸血症，并且已有报道称二者对同型半胱氨酸水平具有协同作用。通过直接神经毒性作用导致血浆同型半胱氨酸水平升高，可能会加速帕金森病潜在的选择性多巴胺能细胞死亡。我们的研究结果支持同型半胱氨酸在帕金森病发病机制中起作用这一假说。
