Diao Hong-Mei, Song Zheng-Feng, Xu Hai-Dong
Department of Neurology, the Central People's Hospital of Tengzhou City, Tengzhou 277500, Shandong, China.
Open Med (Wars). 2019 Aug 17;14:613-624. doi: 10.1515/med-2019-0069. eCollection 2019.
Folate metabolism plays quite a critical role in Parkinson's disease (PD). Previous published research works have studied the link existing between the folate metabolism genetic polymorphisms and PD susceptibility; nevertheless, the results continue having controversies and inconclusiveness. Accordingly, we carried out the present meta-analysis for the assessment of the potential link between the folate metabolism genetic polymorphisms and the susceptibility to PD. In addition we carried out a literature search in the PubMed, EMBASE, Cochrane Library, and WanFang databases till November 10, 2018. The odds ratios (ORs) with corresponding 95% credible interval (95%CI) were put to use for evaluating the strength of the association of three folate metabolism genetic polymorphism ( C677T, A1298C, and A2756G) with the susceptibility to PD. Each statistical analysis was carried out with the use of STATA 15.0. An aggregate of twenty-one case-control investigations were retrieved, which involved 3,944 PD patients and 4,412 controls. We discovered the existence of no substantial link between the C677T and A1298C polymorphism and PD risk in any genetic framework comparisons. With regard to A2756G polymorphism, we discovered that there was an association between the A2756G genetic polymorphism and an augmented threat of PD in the co-dominant genetic framework (GG vs. AA: OR=1.86, 95%CI=1.02-3.37, P=0.042) and the recessive genetic model (GG vs. GA+AA: OR=1.90, 95%CI=1.06-3.41, P=0.031). To summarize, our research work indicates that the A2756G polymorphism of the folate metabolism gene had an association with an augmented threat of PD. Also, A1298C polymorphisms is unlikely to significantly contribute towards the susceptibility to PD. Further large-scale case-control studies are still required.
叶酸代谢在帕金森病（PD）中起着相当关键的作用。先前发表的研究工作已经探讨了叶酸代谢基因多态性与PD易感性之间存在的联系；然而，结果仍然存在争议且尚无定论。因此，我们进行了本次荟萃分析，以评估叶酸代谢基因多态性与PD易感性之间的潜在联系。此外，我们在PubMed、EMBASE、Cochrane图书馆和万方数据库中进行了文献检索，截至2018年11月10日。使用比值比（OR）及其相应的95%可信区间（95%CI）来评估三种叶酸代谢基因多态性（C677T、A1298C和A2756G）与PD易感性之间关联的强度。每项统计分析均使用STATA 15.0进行。共检索到21项病例对照研究，涉及3944例PD患者和4412例对照。在任何遗传框架比较中，我们均未发现C677T和A1298C多态性与PD风险之间存在显著联系。关于A2756G多态性，我们发现在共显性遗传框架（GG vs. AA：OR=1.86，95%CI=1.02-3.37，P=0.042）和隐性遗传模型（GG vs. GA+AA：OR=1.90，95%CI=1.06-3.41，P=0.031）中，A2756G基因多态性与PD风险增加之间存在关联。总之，我们的研究工作表明，叶酸代谢基因的A2756G多态性与PD风险增加有关。此外，A1298C多态性不太可能对PD易感性有显著影响。仍需要进一步的大规模病例对照研究。
