Posthuma Danielle, de Geus Eco J C, Mulder Elles J C M, Smit Dirk J A, Boomsma Dorret I, Stam Cornelis J
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Hum Brain Mapp. 2005 Nov;26(3):191-8. doi: 10.1002/hbm.20156.
Cognitive functions require the integrated activity of multiple specialized, distributed brain areas. Such functional coupling depends on the existence of anatomical connections between the various brain areas as well as physiological processes whereby the activity in one area influences the activity in another area. Recently, the Synchronization Likelihood (SL) method was developed as a general method to study both linear and nonlinear aspects of coupling. In the present study the genetic architecture of the SL in different frequency bands was investigated. Using a large genetically informative sample of 569 subjects from 282 extended twin families we found that the SL is moderately to highly heritable (41-67%) especially in the alpha frequency (8-13 Hz) range. This index of functional connectivity of the brain has been associated with a number of pathological states of the brain. The significant heritability found here suggests that SL can be used to examine the genetic susceptibility to these conditions.
认知功能需要多个专门的、分布于大脑不同区域的脑区进行整合活动。这种功能耦合依赖于不同脑区之间解剖学连接的存在，以及一个脑区的活动能够影响另一个脑区活动的生理过程。最近，同步可能性（SL）方法被开发出来，作为一种研究耦合的线性和非线性方面的通用方法。在本研究中，我们调查了不同频段的同步可能性（SL）的遗传结构。通过对来自282个扩展双胞胎家庭的569名受试者进行的大规模遗传信息样本研究，我们发现同步可能性（SL）具有中度到高度的遗传性（41%-67%），尤其是在α频率（8-13赫兹）范围内。这个大脑功能连接指标与多种脑部病理状态有关。此处发现的显著遗传性表明，同步可能性（SL）可用于检查这些疾病的遗传易感性。
