Zaki Abdelwahab, Chaoui Ahmed Ait, Chait Abderahman, Aboussaouira Touria, Zarrouk Khadija, Himmi Thami
Laboratoire de Physiologie Animale, Faculté des Sciences et Techniques, Béni Mellal, Maroc.
Therapie. 2005 Jan-Feb;60(1):75-9. doi: 10.2515/therapie:2005010.
The aim of our experimental study was to determine the effect of exogenic nitrates on certain biological parameters in relation to renal insufficiency.
Chronic treatment of rats for 5 months with varying nitrate concentrations (50, 100, 150 and 500 mg/L) induced a dose-dependent reduction in plasma concentrations of total proteins and a dose-dependent increase in plasma urea concentrations and creatinine.
This histological study of the kidney shows that nitrates at doses of 150 and 500 mg/L cause a deterioration in the epithelia of the renal tubules.
In conclusion, a high nitrate intake induces morphofunctional disturbances of the kidney and could thus be regarded as a causative factor in renal insufficiency.
我们实验研究的目的是确定外源性硝酸盐对与肾功能不全相关的某些生物学参数的影响。
用不同硝酸盐浓度（50、100、150和500毫克/升）对大鼠进行5个月的慢性治疗，导致血浆总蛋白浓度呈剂量依赖性降低，血浆尿素浓度和肌酐呈剂量依赖性升高。
这项肾脏组织学研究表明，150和500毫克/升剂量的硝酸盐会导致肾小管上皮细胞恶化。
总之，高硝酸盐摄入量会引起肾脏的形态功能紊乱，因此可被视为肾功能不全的一个致病因素。
