Park Won Chan, Han Soo Kyung, Kim Nam Ju, Chung Tae Young, Khwarg Sang In
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Korean J Ophthalmol. 2005 Mar;19(1):1-8. doi: 10.3341/kjo.2005.19.1.1.
To investigate the effect of basic Fibroblast Growth Factor (bFGF) on fibrovascular ingrowth into porous polyethylene orbital implants (Medpor) and to investigate any differences according to the method of administration. For the treated groups, after evisceration and Medpor implantation, bFGF was administered by soaking Medpor in the bFGF solution, and/or by injecting bFGF into the Medpor 1 week after the operation. Implants were removed 4 weeks after the operation and examined for the degrees of fibrovascular ingrowth by light microscopy. The percentages of the cross-sectional area of the implant occupied by fibrovascular ingrowth and the numbers of proliferated vessels were significantly higher in the bFGF-treated groups (Mann Whitney test, p<0.05). Administration routes had no effect on the degree of fibrovascular ingrowth (Kruskal-Wallis test, p>0.05). bFGF promoted fibrovascular ingrowth into porous polyethylene orbital implants regardless of the route of administration. Therefore, bFGF might be helpful to prevent complications such as implant exposure.
研究碱性成纤维细胞生长因子（bFGF）对多孔聚乙烯眼眶植入物（Medpor）纤维血管向内生长的影响，并根据给药方法研究是否存在差异。对于治疗组，在眼球摘除和Medpor植入后，通过将Medpor浸泡在bFGF溶液中，和/或在术后1周将bFGF注入Medpor来给药。术后4周取出植入物，通过光学显微镜检查纤维血管向内生长的程度。在bFGF治疗组中，纤维血管向内生长占据的植入物横截面积百分比和增殖血管数量显著更高（Mann Whitney检验，p<0.05）。给药途径对纤维血管向内生长程度没有影响（Kruskal-Wallis检验，p>0.05）。无论给药途径如何，bFGF均能促进纤维血管向多孔聚乙烯眼眶植入物内生长。因此，bFGF可能有助于预防诸如植入物暴露等并发症。
