Loxton André G, Treurnicht Florette, Laten Annette, van Rensburg Estrelita Janse, Engelbrecht Susan
Department of Medical Virology, National Health Laboratory Service (NHLS) and University of Stellenbosch, Tygerberg Academic Hospital, Tygerberg, 7505, South Africa.
AIDS Res Hum Retroviruses. 2005 May;21(5):410-3. doi: 10.1089/aid.2005.21.410.
South Africa has one of the fastest growing HIV-1 epidemics worldwide, consisting mostly of subtype C. However, HIV-1 subtype B and subtype D viruses were isolated in the beginning of the epidemic in the early 1980s. This study describes the amplification, cloning, and near full-length genome sequencing of four HIV-1 subtype D primary strains, isolated from 1984 to 1986 in Cape Town, in what seems to have been a small restricted subtype D epidemic in the country.
南非是全球艾滋病毒1型疫情增长最快的地区之一，主要流行的是C亚型。然而，在20世纪80年代初疫情开始时就分离出了艾滋病毒1型B亚型和D亚型病毒。本研究描述了1984年至1986年在开普敦分离出的4株艾滋病毒1型D亚型原代毒株的扩增、克隆及近全长基因组测序，该国当时似乎存在一个小规模的局部D亚型疫情。
