人类嗜 T 细胞病毒 1 型与成人 T 细胞白血病：病毒发现 30 年后对病毒转化细胞的深入了解。
HTLV-1 and adult T-cell leukemia: insights into viral transformation of cells 30 years after virus discovery.
机构信息
National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
J Formos Med Assoc. 2010 Oct;109(10):688-93. doi: 10.1016/S0929-6646(10)60112-X.
Abstract
Human T-cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia, was the first human retrovirus to be isolated. It is now the 30(th) anniversary of the initial discovery of HTLV-1. This review discusses recent insights into the role of the HTLV-1 Tax oncoprotein in cellular proliferation and the abrogation of cellular checkpoints that lead to disease progression.
摘要
人类 T 细胞白血病病毒 1 型（HTLV-1）是成人 T 细胞白血病的病原体，也是第一个被分离出来的人类逆转录病毒。现在是最初发现 HTLV-1 的第 30 个年头。这篇综述讨论了最近对 HTLV-1 Tax 癌蛋白在细胞增殖中的作用以及消除导致疾病进展的细胞检查点的见解。
Zotero 插件