雷公藤中的免疫抑制倍半萜。

Immunosuppressive sesquiterpenes from Tripterygium wilfordii.

作者信息

Wang Xiaodong, Gao Wenyuan, Yao Zhi, Zhang Shaoyu, Zhang Yanwen, Takaishi Yoshihisa, Duan Hongquan

机构信息

The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China.

出版信息

Chem Pharm Bull (Tokyo). 2005 Jun;53(6):607-10. doi: 10.1248/cpb.53.607.

DOI:10.1248/cpb.53.607

PMID:15930767

Abstract

Five new sesquiterpenes, 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-4alpha,5alpha-dihydroxy-dihydroagarofuran (1), 1beta,2beta,3alpha,5alpha,7beta,8beta,11-heptaacetoxy-dihydroagarofuran (2), 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-5alpha-hydroxy-dihydroagarofuran (3), 1beta,7beta,8alpha-triacetoxy-2beta-furanoyl-4alpha-hydroxy-11-isobutyryloxy-dihydroagarofuran (4), and 1beta-nicotinoyl-2beta,5alpha,7beta-triacetoxy-4alpha-hydroxy-11-isobutyryloxy-8alpha-furanoyl-dihydroagarofuran (5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6). Their structures were elucidated on the basis of spectroscopic studies. Compounds 2-5 showed significant immunosuppressive activities.

摘要

从雷公藤的木质部中分离出5个新的倍半萜，分别为1β-呋喃甲酰基-2β,3α,7α,8β,11-五乙酰氧基-4α,5α-二羟基-二氢沉香呋喃（1）、1β,2β,3α,5α,7β,8β,11-七乙酰氧基-二氢沉香呋喃（2）、1β-呋喃甲酰基-2β,3α,7α,8β,11-五乙酰氧基-5α-羟基-二氢沉香呋喃（3）、1β,7β,8α-三乙酰氧基-2β-呋喃甲酰基-4α-羟基-11-异丁酰氧基-二氢沉香呋喃（4）和1β-烟酰基-2β,5α,7β-三乙酰氧基-4α-羟基-11-异丁酰氧基-8α-呋喃甲酰基-二氢沉香呋喃（5），同时还分离出1个已知化合物（6）。通过光谱学研究阐明了它们的结构。化合物2 - 5表现出显著的免疫抑制活性。