Barrero Alejandro F, Herrador M Mar, Quílez del Moral José F, Arteaga Pilar, Arteaga Jesús F, Piedra María, Sánchez Elena M
Department of Organic Chemistry, Institute of Biotechnology, University of Granada, Avenida Fuentenueva, 18071 Granada, Spain.
Org Lett. 2005 Jun 9;7(12):2301-4. doi: 10.1021/ol050335r.
[reaction: see text] Titanocene chloride catalyzes the regioselective alpha,alpha'-homocoupling of terpenic allylic halides. This process has been employed in the short and effective synthesis of terpenoids such as beta-onoceradiene (1), beta-onocerin (2), and squalene (3). Evidence is presented for eta1-allyltitanium species being involved in the coupling.
[反应：见正文] 二氯二茂钛催化萜类烯丙基卤化物的区域选择性α,α'-同偶联反应。该方法已用于萜类化合物如β-红没药二烯（1）、β-红没药醇（2）和角鲨烯（3）的短程高效合成。有证据表明η1-烯丙基钛物种参与了该偶联反应。
