强效抗肿瘤聚酮化合物（-）-加利他汀A的全合成
Total synthesis of the potent antitumor polyketide (-)-callystatin A.
作者信息
Dias Luiz C, Meira Paulo R R
机构信息
Instituto de Química, Universidade Estadual de Campinas, UNICAMP, C. P. 6154, CEP 13084-971, Campinas, SP, Brazil.
出版信息
J Org Chem. 2005 Jun 10;70(12):4762-73. doi: 10.1021/jo050352u.
PMID:15932316
Abstract
A highly convergent and efficient total synthesis of the potent antitumor polyketide (-)-callystatin A is described. The synthesis required 19 steps from N-propionyl oxazolidinone 23 and produced the desired product in 3.5% overall yield.
摘要
本文描述了高效全合成强效抗肿瘤聚酮化合物（-）-抑癌素A的方法。该合成方法以N-丙酰基恶唑烷酮23为起始原料，经过19步反应，总产率为3.5%，得到了目标产物。
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