Hanif Madiha, Mansha Asim, Ali Kulsoom Ghulam, Saeed Muhammad Athar, Mahmood Shahid, Chaudhry Aijaz Rasool, Irfan Ahmad, Mushtaq Aqsa, Zahoor Ameer Fawad
Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Institute for Advanced Interdisciplinary Research (IAIR), School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, Shandong, People's Republic of China.
Mol Divers. 2024 Dec 9. doi: 10.1007/s11030-024-11057-7.
Epoxides are significant heterocycles in the structural makeup of a variety of natural products. Their ring-opening reactions have emerged as a versatile and efficient strategies for synthesizing a variety of functionalized molecules. Such reactions have been extensively applied towards the preparation of complex naturally occurring products. The focus on epoxide ring-opening reactions within the scientific community has been increased, influenced by the goal to understand the synthesis of compounds that are important for their biological and structural significance. In this article, we have provided a concise account on the applications of epoxide's ring cleavage towards the syntheses of polyketides and related naturally occurring compounds, documented since last decade (2014-2023).
环氧化合物是多种天然产物结构组成中的重要杂环化合物。它们的开环反应已成为合成各种功能化分子的通用且高效的策略。此类反应已广泛应用于复杂天然产物的制备。受理解对生物学和结构具有重要意义的化合物合成这一目标的影响，科学界对环氧化合物开环反应的关注有所增加。在本文中，我们简要介绍了自上一个十年（2014 - 2023年）以来有记录的环氧化合物开环反应在聚酮化合物及相关天然产物合成中的应用。
