Méric Jean-Baptiste, Morère Jean-François
Service d'Oncologie Médicale, Hôpital Pitié-Salpêtrière, 43-87 bd de l'Hôpital, 75013 Paris.
Bull Cancer. 2005 May 1;92(5):439-44.
Anemia and fatigue are frequent in lung cancer patients. Anemia is due to cancer and platinum-based chemotherapy. Anemia leads to a wide range of symptoms and affects health-related quality of life. Anemia also worsens outcome of therapy and prognosis. Efficient treatment exist: blood transfusion and recombinant erythropoietin. Early treatment of anemia is recommended as soon as diagnosis is made. But few patients receive optimal treatment. Its cost and unsolved question regarding therapeutic strategies may explain this phenomenon. This debate should not preclude correct treatment prescription. Clinical trials have to be preformed to clarify unsolved questions. As EPO administration can affect survival, this point should be of particular interest in future trials.
贫血和疲劳在肺癌患者中很常见。贫血是由癌症和铂类化疗引起的。贫血会导致一系列症状，并影响与健康相关的生活质量。贫血还会使治疗结果和预后恶化。有有效的治疗方法：输血和重组促红细胞生成素。建议在确诊后尽早对贫血进行早期治疗。但很少有患者接受最佳治疗。其成本以及治疗策略方面尚未解决的问题可能解释了这一现象。这场争论不应妨碍正确的治疗处方。必须进行临床试验以澄清未解决的问题。由于促红细胞生成素的使用会影响生存，这一点在未来的试验中应特别受到关注。
