Eandi Chiara M, Chung Juliet E, Cardillo-Piccolino Felice, Spaide Richard F
University Eye Clinic, University of Torino, Torino, Italy.
Retina. 2005 Jun;25(4):417-21. doi: 10.1097/00006982-200506000-00004.
To evaluate the correlation between optical coherence tomographic evaluations of foveal thickness and anatomical changes within the fovea and visual acuity in patients who have unilateral resolved central serous chorioretinopathy.
A retrospective review of cases of unilateral resolved central serous chorioretinopathy imaged with high-resolution optical coherence tomography was performed. The foveal thickness of the involved eye was normalized by dividing its thickness by that of the uninvolved fellow eye. The best-corrected visual acuity of the involved eye was normalized as well. The normalized foveal thickness was compared with the normalized visual acuity. The anatomical findings of the fovea were compared with the visual acuity.
Twenty patients were evaluated (11 men and 9 women; age range, 31-66 years [mean, 46.8 years]). The mean foveal thickness was 135.8 mum in the involved eyes and 184.4 mum in the uninvolved eyes (P < 0.001). There was a correlation between the normalized foveal thickness and the normalized visual acuity (Spearman rho, 0.67; P = 0.001). The external limiting membrane was visible in 7 (35%) of the involved eyes compared with 19 uninvolved eyes (95%) (P < 0.001). In the involved eyes, those with a visible external limiting membrane had better visual acuity than did those that did not (P = 0.001). It was possible to visualize the boundary between the photoreceptor cell bodies and the outer segments in 8 (40%) of the involved eyes and in the 17 uninvolved eyes (85%) (P < 0.001). In the involved eyes, those with a visible boundary between the photoreceptor bodies and the outer segments had a better visual acuity than did those that did not (P = 0.019).
Patients with unilateral resolved central serous chorioretinopathy had a decrease in the central foveal thickness in the involved eyes, and there was a statistically significant correlation between the foveal thickness and the visual acuity, even in eyes with relatively good visual acuity. The inability to observe a discrete signal corresponding to the external limiting membrane layer was more common in involved eyes and was significantly associated with decreased visual acuity. This same relationship was seen with the ability to visualize the boundary between the photoreceptor bodies and the outer segments; this boundary was less commonly observed in involved eyes and was associated with decreased visual acuity. Resolved central serous chorioretinopathy causes a number of morphologic changes in the fovea that are associated with visual acuity.
评估单侧已治愈的中心性浆液性脉络膜视网膜病变患者的黄斑厚度光学相干断层扫描评估结果与黄斑部解剖结构变化及视力之间的相关性。
对采用高分辨率光学相干断层扫描成像的单侧已治愈的中心性浆液性脉络膜视网膜病变病例进行回顾性研究。将患眼的黄斑厚度除以未患侧对侧眼的黄斑厚度进行标准化。患眼的最佳矫正视力也进行标准化。比较标准化后的黄斑厚度与标准化后的视力。比较黄斑部的解剖学发现与视力。
共评估了20例患者（11例男性和9例女性；年龄范围31 - 66岁[平均46.8岁]）。患眼中黄斑平均厚度为135.8μm，未患眼中为184.4μm（P < 0.001）。标准化后的黄斑厚度与标准化后的视力之间存在相关性（Spearman秩相关系数，0.67；P = 0.001）。患眼中7只（35%）可见外界膜，而未患眼中19只（95%）可见外界膜（P < 0.001）。在患眼中，可见外界膜的患者视力优于未见外界膜的患者（P = 0.001）。患眼中8只（40%）能观察到光感受器细胞体与外节之间的边界，未患眼中17只（85%）能观察到（P < 0.001）。在患眼中，能观察到光感受器细胞体与外节之间边界的患者视力优于未观察到的患者（P = 0.019）。
单侧已治愈的中心性浆液性脉络膜视网膜病变患者患眼的中心黄斑厚度降低，即使在视力相对较好的眼中，黄斑厚度与视力之间也存在统计学上的显著相关性。患眼中更常见无法观察到与外界膜层对应的离散信号，这与视力下降显著相关。光感受器细胞体与外节之间边界的观察情况也呈现相同关系；患眼中较少观察到该边界，且与视力下降相关。已治愈的中心性浆液性脉络膜视网膜病变会导致黄斑部出现一些与视力相关的形态学变化。
