Nakamura Tomoko, Ueda-Consolvo Tomoko, Oiwake Toshihiko, Hayashi Atsushi
Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Graefes Arch Clin Exp Ophthalmol. 2016 Dec;254(12):2347-2354. doi: 10.1007/s00417-016-3403-1. Epub 2016 Jun 2.
We aimed to observe photoreceptors and outer retinal layer thickness by using an adaptive optics (AO) fundus camera and spectral domain optical coherence tomography (SD-OCT) in patients with central serous chorioretinopathy (CSC).
Twelve eyes of 12 patients with resolved CSC were studied. After subretinal fluid (SRF) had resolved, AO images of the macula were obtained by using the rtx1 AO fundus camera (Imagine Eyes, France). Cones in the nasal and temporal areas of the macula, 0.5 mm from the foveal center, were counted. Outer retinal layer thickness was measured as the distance between the outer border of external limiting membrane (ELM) and the inner border of retinal pigment epithelium (RPE) at 0.5 mm from the foveal center. The first measurement was performed after resolution of the subretinal fluid and was defined as the baseline. Then, the second measurement was performed in the same location after 12 months.
In the eyes with resolved CSC, the mean logMAR values of visual acuity at baseline and 12 months were 0.16 and 0.01, respectively (p = 0.0023). The mean cone densities at baseline and 12 months were 12,213 and 17,146 cones/mm, respectively. The mean cone densities at 12 months were significantly increased compared to baseline (p = 0.0014). The mean outer retinal layer thickness at baseline (53.5 μm) was significantly thinner than that at 12 months (60.7 μm) (p = 0.0013). The mean cone densities were significantly correlated with outer retinal layer thickness and logMAR visual acuity.
Adaptive optics imaging revealed a gradual increase in the number of macular cone densities during 12 months in patients with resolved CSC, which was correlated with outer retinal layer thickness and visual acuity in a short term.
我们旨在使用自适应光学（AO）眼底相机和光谱域光学相干断层扫描（SD-OCT）观察中心性浆液性脉络膜视网膜病变（CSC）患者的光感受器和视网膜外层厚度。
对12例CSC已缓解患者的12只眼睛进行研究。视网膜下液（SRF）消退后，使用rtx1 AO眼底相机（法国Imagine Eyes公司）获取黄斑区的AO图像。计数黄斑区距中心凹中心0.5毫米处鼻侧和颞侧区域的视锥细胞。将视网膜外层厚度测量为距中心凹中心0.5毫米处外部限制膜（ELM）外边界与视网膜色素上皮（RPE）内边界之间的距离。第一次测量在视网膜下液消退后进行，并定义为基线。然后，在12个月后于同一位置进行第二次测量。
在CSC已缓解的眼睛中，基线和12个月时的平均logMAR视力值分别为0.16和0.01（p = 0.0023）。基线和12个月时的平均视锥细胞密度分别为12,213个/mm和17,146个/mm。12个月时的平均视锥细胞密度与基线相比显著增加（p = 0.0014）。基线时的平均视网膜外层厚度（53.5μm）显著薄于12个月时的厚度（60.7μm）（p = 0.0013）。平均视锥细胞密度与视网膜外层厚度和logMAR视力显著相关。
自适应光学成像显示，CSC已缓解的患者在12个月内黄斑区视锥细胞密度逐渐增加，这与短期内视网膜外层厚度和视力相关。
