Gallardo F, Rossi E
Department of Pharmacology, School of Medicine, University of Chile, Santiago.
J Periodontol. 1992 Mar;63(3):166-8. doi: 10.1902/jop.1992.63.3.166.
The analgesic activity of single doses of meclofenamate (100 mg) was compared to aspirin (500 mg) and to placebo on 99 outpatients with moderate to severe pain following periodontal surgery under double-blind conditions. Pain intensity differences scores (PID) at the first, second, and third hour after the ingestion of the first capsule of each medication were used to determine the analgesic efficacy of the studied drugs. Kruskal Wallis test followed by the Mann-Whitney rank sum test were used in the statistical analysis of results. Meclofenamate was statistically superior to placebo and superior to aspirin in the second hour of evaluation, while aspirin was not superior to placebo during the 3-hour period of pain evaluation. It is concluded that meclofenamate is a non-steroidal antiinflammatory drug with interesting analgesic properties which can be used as directed as an alternative to aspirin or acetaminophen for the control of postoperative pain following periodontal surgery.
在双盲条件下，对99名接受牙周手术后有中度至重度疼痛的门诊患者，比较了单剂量甲氯芬那酸（100毫克）、阿司匹林（500毫克）和安慰剂的镇痛活性。服用每种药物的第一粒胶囊后第一、第二和第三小时的疼痛强度差异评分（PID）用于确定所研究药物的镇痛效果。结果的统计分析采用Kruskal Wallis检验，随后进行Mann-Whitney秩和检验。在评估的第二小时，甲氯芬那酸在统计学上优于安慰剂且优于阿司匹林，而在3小时的疼痛评估期间，阿司匹林并不优于安慰剂。结论是，甲氯芬那酸是一种具有有趣镇痛特性的非甾体抗炎药，可按指示用作阿司匹林或对乙酰氨基酚的替代品，用于控制牙周手术后的术后疼痛。
