Yonkeura M L, Petrone S, Turner J L, di Zerega G S
Women's Hospital, Los Angeles County, California.
Clin Ther. 1987;9(6):578-84.
Meclofenamate sodium, a nonsteroidal anti-inflammatory agent, was compared at two dose levels (100 mg and 200 mg) with codeine (60 mg) and placebo in a double-blind, randomized study of 218 women after normal vaginal delivery. The purpose was to determine the analgesic efficacy and safety of meclofenamate sodium for the short-term treatment of acute episiotomy pain. Meclofenamate sodium was significantly better than placebo in most measures of pain relief and reduction of pain intensity. The 100-mg dose of meclofenamate sodium was significantly better than codeine in relieving pain. Adverse experiences with the study medications were minimal (6.4%). Patients receiving codeine reported more side effects than did those receiving either dose of meclofenamate sodium. Meclofenamate sodium is a safe, effective analgesic for acute episiotomy pain.
在一项针对218名正常阴道分娩后女性的双盲、随机研究中，将非甾体抗炎药甲氯芬那酸钠在两个剂量水平（100毫克和200毫克）下与可待因（60毫克）及安慰剂进行了比较。目的是确定甲氯芬那酸钠用于短期治疗急性会阴切开术疼痛的镇痛效果和安全性。在大多数疼痛缓解和疼痛强度降低的指标上，甲氯芬那酸钠明显优于安慰剂。100毫克剂量的甲氯芬那酸钠在缓解疼痛方面明显优于可待因。研究药物的不良事件极少（6.4%）。接受可待因的患者报告的副作用比接受任何一个剂量甲氯芬那酸钠的患者都多。甲氯芬那酸钠是治疗急性会阴切开术疼痛的一种安全、有效的镇痛药。
