Cavallo Federica, Curcio Claudia, Forni Guido
University of Turin, Department of Clinical and Biological Sciences, Ospedale San Luigi Gonzaga, I-10043 Orbassano, Italy.
Expert Opin Biol Ther. 2005 May;5(5):717-26. doi: 10.1517/14712598.5.5.717.
Although evolution has shaped the immune system to control microbial invasions, this does not necessarily mean that the immune system can not be triggered to eliminate tumour cells. The exploitation of the terrific potential of the immune system to recognise cell alterations and to selectively destroy large populations of neoplastic cells is a possibility made even more attractive by the advances in our understanding of the immune mechanisms and our ability to manipulate them. This review summarises the state of the different immunotherapy strategies available or in development today, and examines the future developments that hold out the promise of an effective control of cancer growth.
尽管进化塑造了免疫系统以控制微生物入侵，但这并不一定意味着免疫系统不能被触发来消除肿瘤细胞。免疫系统具有识别细胞改变并选择性摧毁大量肿瘤细胞的巨大潜力，随着我们对免疫机制理解的进步以及操纵这些机制能力的提升，利用这一潜力变得更具吸引力。本综述总结了目前可用或正在研发的不同免疫治疗策略的现状，并探讨了有望有效控制癌症生长的未来发展方向。
