Berzofsky Jay A, Terabe Masaki, Oh SangKon, Belyakov Igor M, Ahlers Jeffrey D, Janik John E, Morris John C
Molecular Immunogenetics and Vaccine Research Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
J Clin Invest. 2004 Jun;113(11):1515-25. doi: 10.1172/JCI21926.
In recent years, great strides in understanding and regulating the immune system have led to new hope for harnessing its exquisite specificity to destroy cancer cells without affecting normal tissues. This review examines the fundamental immunologic advances and the novel vaccine strategies arising from these advances, as well as the early clinical trials studying new approaches to treat or prevent cancer.
近年来,在理解和调控免疫系统方面取得的巨大进展为利用其精准的特异性来摧毁癌细胞而不影响正常组织带来了新希望。本综述探讨了基础免疫学进展以及由此产生的新型疫苗策略,以及研究治疗或预防癌症新方法的早期临床试验。