Taylor L J, Bagg J, Walker D M, Peters T J
Department of Oral Surgery, University of Wales, Cardiff.
J Oral Pathol Med. 1992 Jan;21(1):21-5. doi: 10.1111/j.1600-0714.1992.tb00963.x.
Much evidence suggests that recurrent oral aphthous ulceration (RAU) is an immunologically mediated disease. Tumour necrosis factor has multiple biologic properties, some of which may be relevant to the pathogenesis of RAU. This study has assessed its production by peripheral blood leukocytes from aphthous patients in active and remission phases of disease and from patients with nonaphthous ulceration (diseased controls). Each ulcer patient was studied in parallel with a matched healthy control volunteer. A bioassay against the standard mouse fibrosarcoma line, L929, was used to assess the levels of tumour necrosis factor-alpha (TNF). Significantly greater amounts of TNF were released from unstimulated monocyte-enriched and monocyte-depleted leukocyte fractions in active RAU compared with those from healthy control donors, suggesting that this cytokine may be associated with RAU.
大量证据表明，复发性口腔溃疡（RAU）是一种免疫介导的疾病。肿瘤坏死因子具有多种生物学特性，其中一些可能与RAU的发病机制有关。本研究评估了处于疾病活动期和缓解期的口疮患者以及患有非口疮性溃疡的患者（疾病对照）外周血白细胞中肿瘤坏死因子的产生情况。每位溃疡患者均与一名匹配的健康对照志愿者进行平行研究。采用针对标准小鼠纤维肉瘤细胞系L929的生物测定法来评估肿瘤坏死因子-α（TNF）的水平。与健康对照供体相比，活动期RAU患者未受刺激的富含单核细胞和去除单核细胞的白细胞组分释放出的TNF量显著更多，这表明这种细胞因子可能与RAU有关。
