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一名HIV患者复发性阿弗他溃疡的治疗——己酮可可碱的新用途。

Treatment of recurrent aphthous ulcers in an HIV patient - An emerging use for pentoxifylline.

作者信息

Slayter K L, Marrie T J

机构信息

College of Pharmacy, Dalhousie University;

出版信息

Can J Infect Dis. 1998 May;9(3):189-90. doi: 10.1155/1998/569317.

DOI:10.1155/1998/569317
PMID:22346543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3250908/
Abstract

Patients with human immunodeficiency virus (HIV) infection often suffer from persistent, painful ulcers that commonly occur on the soft palate, buccal mucosa, tonsillar area or tongue, which are referred to as aphthous ulcers. This paper reports the case in which pentoxifylline was successfully used to treat recurrent aphthous ulcers in an HIV patient.

摘要

感染人类免疫缺陷病毒（HIV）的患者经常遭受持续的、疼痛性溃疡的折磨，这些溃疡通常发生在软腭、颊黏膜、扁桃体区域或舌头，被称为阿弗他溃疡。本文报告了己酮可可碱成功用于治疗一名HIV患者复发性阿弗他溃疡的病例。

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Treatment of recurrent aphthous ulcers in an HIV patient - An emerging use for pentoxifylline.一名HIV患者复发性阿弗他溃疡的治疗——己酮可可碱的新用途。
Can J Infect Dis. 1998 May;9(3):189-90. doi: 10.1155/1998/569317.
2
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Major aphthous ulcers in patients with HIV disease.感染人类免疫缺陷病毒（HIV）患者的重型阿弗他溃疡
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Recurrent aphthous stomatitis: clinical characteristics and associated systemic disorders.复发性阿弗他口炎：临床特征及相关全身性疾病
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本文引用的文献

1
Oral manifestations of HIV infection.HIV感染的口腔表现。
Ann Intern Med. 1996 Sep 15;125(6):485-96. doi: 10.7326/0003-4819-125-6-199609150-00010.
2
Thalidomide for aphthous ulcers in patients infected with the human immunodeficiency virus.沙利度胺用于感染人类免疫缺陷病毒患者的口腔溃疡
Am J Health Syst Pharm. 1996 Feb 15;53(4):368, 371-2, 378. doi: 10.1093/ajhp/53.4.368.
3
Successful treatment of Behçet disease with pentoxifylline.
Ann Intern Med. 1996 May 15;124(10):891-3. doi: 10.7326/0003-4819-124-10-199605150-00005.
4
Pentoxifylline aggravates impairment in tumor necrosis factor-alpha secretion and increases mycobacterial load in macrophages from AIDS patients with disseminated Mycobacterium avium-intracellulare complex infection.己酮可可碱会加重肿瘤坏死因子-α分泌的损伤，并增加患有播散性鸟分枝杆菌复合群感染的艾滋病患者巨噬细胞中的分枝杆菌载量。
J Infect Dis. 1994 Aug;170(2):484-7. doi: 10.1093/infdis/170.2.484.
5
Pentoxifylline for the treatment of infection with human immunodeficiency virus.己酮可可碱用于治疗人类免疫缺陷病毒感染。
Clin Infect Dis. 1994 Mar;18(3):285-7. doi: 10.1093/clinids/18.3.285.
6
Pentoxifylline in intractable recurrent aphthous stomatitis: an open trial.己酮可可碱治疗顽固性复发性阿弗他口炎：一项开放性试验。
J Am Acad Dermatol. 1995 Oct;33(4):680-2. doi: 10.1016/0190-9622(95)91310-6.
7
Treatment of recurrent aphthous stomatitis with pentoxifylline.己酮可可碱治疗复发性阿弗他口炎
Br J Dermatol. 1995 Oct;133(4):659-60. doi: 10.1111/j.1365-2133.1995.tb02728.x.
8
Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline.己酮可可碱对肿瘤坏死因子-α产生的细胞和分子调节
Biochem Biophys Res Commun. 1988 Sep 30;155(3):1230-6. doi: 10.1016/s0006-291x(88)81271-3.
9
Major aphthous-like ulcers in patients with AIDS.艾滋病患者中的重型口疮样溃疡。
Oral Surg Oral Med Oral Pathol. 1991 Jan;71(1):68-72. doi: 10.1016/0030-4220(91)90524-g.
10
Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration.复发性口腔阿弗他溃疡患者外周血白细胞肿瘤坏死因子产生增加。
J Oral Pathol Med. 1992 Jan;21(1):21-5. doi: 10.1111/j.1600-0714.1992.tb00963.x.