Slabbert H, Altini M, Crooks J, Uys P
Department of Oral Pathology, University of the Witwatersrand, Johannesburg.
J Oral Pathol Med. 1992 Jan;21(1):46-8. doi: 10.1111/j.1600-0714.1992.tb00969.x.
Ameloblastomas do not generally show evidence of induction, however rare cases associated with an odontome have been reported, and are referred to as odontoameloblastoma. In this paper the first known case of an ameloblastoma showing evidence of induction of dentinoid by tumor cells but without concomitant formation of enamel is recorded. The lesion occurred in the angle and ramus of the mandible of a 24-yr-old Asian man and was largely unicystic. In one area however, solid tumor was present which consisted both of infiltrating follicles of typical ameloblastoma tissue and solid sheets of ovoid to spindle cells containing abundant amounts of a homogenous eosinophilic extracellular material, interpreted as dentinoid, and psammamomatous type dystrophic calcifications. Electron microscopic examination of formalin-fixed tissue showed this dentinoid material to consist of interlacing collagen fibrils embedded in a structureless ground substance. At the periphery of the dentinoid globules the collagen fibres were arranged in parallel layers. A final diagnosis of dentinoameloblastoma was made.
成釉细胞瘤一般无诱导证据，但有罕见病例报告与牙瘤相关，称为牙源性成釉细胞瘤。本文记录了首例有肿瘤细胞诱导类牙本质形成但无釉质形成的成釉细胞瘤病例。该病变发生于一名24岁亚洲男性下颌角及升支，主要为单囊性。然而，在一个区域存在实性肿瘤，由典型成釉细胞瘤组织的浸润性滤泡和由卵圆形至梭形细胞组成的实性片层构成，这些细胞含有大量均匀嗜酸性细胞外物质，被解释为类牙本质，还有砂粒体样营养不良性钙化。对福尔马林固定组织的电子显微镜检查显示，这种类牙本质物质由交织的胶原纤维组成，包埋于无结构的基质中。在类牙本质小球周边，胶原纤维呈平行层排列。最终诊断为牙本质成釉细胞瘤。
