Sharma Gitika, Kamboj Mala, Narwal Anjali, Devi Anju, Singh Virendra
Dept. of Oral and Maxillofacial Pathology and Oral Microbiology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana India.
Dept. of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Rohtak, India.
Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):2432-2437. doi: 10.1007/s12070-023-03534-6. Epub 2023 Apr 8.
Introduction: Odontogenic tumors encompass a heterogeneous group of lesions that range from hamartomatous lesions to malignancy. Considerable variation in histologic presentation can mislead their accurate diagnosis and categorization. Ameloblastoma is generally well understood and is easy to diagnose but there has been a constant change in the classification systems ever since Broca classified odontogenic tumors in the year 1867. Over the years, it has been modified by the World Health Organization with many additions and omissions. This dynamic change is based on the result and conclusions of molecular and genetic studies with the last modification in 2017. Case Report: We present two cases of females aged 32 and 60 years who reported with facial swellings, revealed the presence of distinct histopathological findings and were diagnosed as ameloblastoma with dentinoid or adenoid ameloblastoma. Literature search revealed dearth of distinct forms of ameloblastoma that show the formation of duct like structures and dentinoid. Conclusion: It is interesting to highlight such cases as the biological behavior is still unexplored due to paucity of relevant studies and follow up of patients. Understanding the pathogenesis and the histopathological characteristics of the newer entities will enable the prompt diagnosis, treatment plan and expanding the spectrum of the lesions.
The online version contains supplementary material available at 10.1007/s12070-023-03534-6.
引言：牙源性肿瘤是一组异质性病变，范围从错构瘤性病变到恶性病变。组织学表现的显著差异可能会误导其准确诊断和分类。成釉细胞瘤通常易于理解且易于诊断，但自1867年布罗卡对牙源性肿瘤进行分类以来，分类系统一直在不断变化。多年来，世界卫生组织对其进行了修改，有许多增减。这种动态变化基于分子和遗传学研究的结果和结论，最近一次修改是在2017年。病例报告：我们报告两例女性患者，年龄分别为32岁和60岁，因面部肿胀就诊，显示出独特的组织病理学表现，被诊断为含牙本质样或腺样成釉细胞瘤。文献检索发现缺乏显示导管样结构和牙本质样形成的独特形式的成釉细胞瘤。结论：突出此类病例很有意思，因为由于相关研究和患者随访较少，其生物学行为仍未得到探索。了解新实体的发病机制和组织病理学特征将有助于及时诊断、制定治疗方案并扩大病变范围。
在线版本包含可在10.1007/s12070-023-03534-6获取的补充材料。
