Omoigui Sota
Division of Inflammation and Pain Research, L.A. Pain Clinic, 4019 W. Rosecrans Avenue, Hawthorne, CA 90250, USA.
Med Hypotheses. 2005;65(3):559-69. doi: 10.1016/j.mehy.2005.03.012.
This is a unifying theory that cholesterol metabolites (isoprenoids) are an integral component of the signaling pathway for interleukin-6 (IL-6) mediated inflammation. IL-6 inflammation is the common causative origin for atherosclerosis, peripheral vascular disease, coronary artery disease, and age-related disorders including osteoporosis, dementia, Alzheimer's disease and type 2 diabetes. Therapeutic effects of bisphosphonates and statins are mediated by isoprenoid depletion. Statins and bisphosphonates act in the cholesterol pathway to deplete isoprenoids. Anti-inflammatory properties of statins and bisphosphonates are due to isoprenoid depletion with subsequent inhibition of IL-6 mediated inflammation. Therapeutic targets for the prevention and control of all the above diseases should focus on cholesterol metabolites and IL-6 mediated inflammation. Prevention of atherosclerotic vascular disease and age-related disorders will be by utilization of cholesterol lowering agents or techniques and/or treatment with statins and/or bisphosphonates to inhibit IL-6 inflammation through regulation of cholesterol metabolism.
这是一个统一的理论，即胆固醇代谢产物（类异戊二烯）是白细胞介素-6（IL-6）介导的炎症信号通路的一个组成部分。IL-6炎症是动脉粥样硬化、外周血管疾病、冠状动脉疾病以及包括骨质疏松症、痴呆症、阿尔茨海默病和2型糖尿病在内的与年龄相关疾病的常见病因。双膦酸盐和他汀类药物的治疗作用是由类异戊二烯耗竭介导的。他汀类药物和双膦酸盐作用于胆固醇途径以消耗类异戊二烯。他汀类药物和双膦酸盐的抗炎特性归因于类异戊二烯耗竭以及随后对IL-6介导的炎症的抑制。预防和控制上述所有疾病的治疗靶点应聚焦于胆固醇代谢产物和IL-6介导的炎症。预防动脉粥样硬化性血管疾病和与年龄相关的疾病将通过使用降胆固醇药物或技术和/或用他汀类药物和/或双膦酸盐进行治疗，以通过调节胆固醇代谢来抑制IL-6炎症。
