Omoigui Sota
Division of Inflammation and Pain Medicine, LA Pain Clinic, 4019 W Rosecrans Ave, Los Angeles, CA 90250, USA.
Immun Ageing. 2007 Mar 20;4:1. doi: 10.1186/1742-4933-4-1.
We describe the inflammation pathway from Cholesterol to Aging. Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, Osteoporosis, Type 2 Diabetes, Dementia and Alzheimer's disease and some forms of Arthritis and Cancer. Statins and Bisphosphonates inhibit Interleukin 6 mediated inflammation indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion. Polyphenolic compounds found in plants, fruits and vegetables inhibit Interleukin 6 mediated inflammation by direct inhibition of the signal transduction pathway. Therapeutic targets for the control of all the above diseases should include inhibition of Interleukin-6 mediated inflammation.
我们描述了从胆固醇到衰老的炎症途径。白细胞介素6介导的炎症与包括动脉粥样硬化、外周血管疾病、冠状动脉疾病、骨质疏松症、2型糖尿病、痴呆症和阿尔茨海默病以及某些形式的关节炎和癌症在内的与年龄相关的疾病有关。他汀类药物和双膦酸盐通过调节内源性胆固醇合成和类异戊二烯耗竭间接抑制白细胞介素6介导的炎症。在植物、水果和蔬菜中发现的多酚类化合物通过直接抑制信号转导途径来抑制白细胞介素6介导的炎症。控制上述所有疾病的治疗靶点应包括抑制白细胞介素-6介导的炎症。
