氧化还原再探：重新审视蛋白酪氨酸磷酸酶与细胞信号传导的控制
Redox redux: revisiting PTPs and the control of cell signaling.
作者信息
Tonks Nicholas K
机构信息
Cold Spring Harbor Laboratory, New York 11724, USA.
出版信息
Cell. 2005 Jun 3;121(5):667-70. doi: 10.1016/j.cell.2005.05.016.
PMID:15935753
Abstract
The architecture of the active site of members of the protein tyrosine phosphatase (PTP) superfamily renders these enzymes sensitive to reversible oxidation and inactivation. The importance of reversible oxidation of PTP superfamily members in controlling the signal output following an extracellular stimulus is discussed.
摘要
蛋白质酪氨酸磷酸酶（PTP）超家族成员活性位点的结构使这些酶对可逆氧化和失活敏感。本文讨论了PTP超家族成员的可逆氧化在控制细胞外刺激后信号输出方面的重要性。
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