Pascual E, Castellano J A
Rheumatology Section, Hospital General de Alicante, Spain.
J Rheumatol. 1992 Apr;19(4):600-3.
Synovial fluid (SF) samples, all containing monosodium urate crystals, obtained from 18 asymptomatic knees of 12 patients with gout, were serially analyzed before and one month after treatment with 1 mg/day of oral colchicine. Before treatment, the SF contained 612 [confidence limits (CL) = 282, 942] cells/mm3, while after treatment these values decreased to 274 (CL = 73, 471) cells/mm3 (p less than 0.005). In all cases, pretreatment cell counts were higher than the corresponding posttreatment values. The percentage of polymorphonuclear leukocytes also diminished from a pretreatment value of 13.0 (CL = 7, 19) to 4.5 (CL = 2, 7) after colchicine administration (p less than 0.005). These results strongly suggest the presence of baseline subclinical joint inflammation which is reduced by colchicine. The preventive effect of this drug on the occurrence of new attacks may relate to its effect in reducing the baseline inflammation of the asymptomatic joints.
从12例痛风患者的18个无症状膝关节获取的滑膜液（SF）样本均含有尿酸钠晶体，在给予每日1毫克秋水仙碱口服治疗前及治疗后1个月进行了系列分析。治疗前，滑膜液中含有612[置信区间（CL）=282, 942]个细胞/mm³，而治疗后这些数值降至274（CL = 73, 471）个细胞/mm³（p<0.005）。在所有病例中，治疗前的细胞计数均高于相应的治疗后数值。多形核白细胞的百分比也从秋水仙碱给药前的13.0（CL = 7, 19）降至4.5（CL = 2, 7）（p<0.005）。这些结果有力地表明存在基线亚临床关节炎症，秋水仙碱可使其减轻。该药物对新发作的预防作用可能与其减轻无症状关节基线炎症的作用有关。
