Louwrens H D, Adamson J, Powell J T, Greenhalgh R M
Department of Surgery, Charing Cross & Westminster Medical School, London, U.K.
Int Angiol. 1993 Mar;12(1):21-4.
Risk factors associated with atherosclerosis were compared in 2 groups of men: with aneurysmal dilatation (AAA) or stenosing disease (SAD) of the infrarenal aorta. In the AAA group (N = 114) the median aortic diameter was 6.9 cm and 89% of patients had undergone elective or emergency surgical repair. In the SAD group (N = 57) an equal proportion had had an aortobifemoral bypass, the median aortic diameter was 1.8 cm. Men with AAA were older (73 years vs 68 years; p < 0.001). There were no differences in total cholesterol and triglycerides between the two but men with AAA had a higher HDL-cholesterol concentration (1.22 mmol/l vs 1.08 mmol/l; p = 0.019). Tobacco consumption in the 2 groups was similar (36.5 pack years vs 35.0 pack years; p = 0.387). After correction for age, diastolic blood pressure was significantly higher in the AAA group. In both groups there is extensive aortic atherosclerosis but differences between the two groups indicate that stenosing and dilating disease are distinct pathological entities.
一组患有肾下腹主动脉瘤样扩张（AAA），另一组患有肾下腹主动脉狭窄性疾病（SAD）。在AAA组（N = 114）中，主动脉直径中位数为6.9 cm，89%的患者接受了择期或急诊手术修复。在SAD组（N = 57）中，接受主动脉双股动脉旁路移植术的比例相同，主动脉直径中位数为1.8 cm。患有AAA的男性年龄更大（73岁对68岁；p < 0.001）。两组之间的总胆固醇和甘油三酯没有差异，但患有AAA的男性高密度脂蛋白胆固醇浓度更高（1.22 mmol/l对1.08 mmol/l；p = 0.019）。两组的吸烟量相似（36.5包年对35.0包年；p = 0.387）。校正年龄后，AAA组的舒张压明显更高。两组均存在广泛的主动脉粥样硬化，但两组之间的差异表明，狭窄性疾病和扩张性疾病是不同的病理实体。
