色素性视网膜炎患者的血浆内皮素-1浓度
Endothelin-1 plasma concentrations in patients with retinitis pigmentosa.
作者信息
Vingolo E M, Lupo S, Grenga P L, Salvatore S, Zinnamosca L, Cotesta D, Petramala L, Letizia C
机构信息
Department of Ophthalmology, University of Rome Sapienza, A. Fiorini Hospital Terracina (LT), Italy.
出版信息
Regul Pept. 2010 Feb 25;160(1-3):64-7. doi: 10.1016/j.regpep.2009.12.006. Epub 2009 Dec 11.
PURPOSE
The aim of this study was to investigate the behaviour of plasma endothelin-1 (ET-1) levels in patients affected by retinitis pigmentosa (RP) and syndromic RP.
METHODS
Blood samples were obtained from a group of 40 consecutive patients with RP matched with 35 healthy subjects (HS) as control. We carried out a complete ophthalmological examination. The study group included 26 patients with RP and 14 patients with syndromic RP. Plasma ET-1 levels were determined in duplicate with a specific radioimmunoassay method.
RESULTS
In the HS plasma ET-1 levels were 7.48+/-2.58 pg/mL. The mean of plasma ET-1 concentrations in all patients with RP ( 16.2+/-5.6 pg/mL) was significantly (P<0.01) higher than that of HS. Moreover, in the syndromic RP patients, plasma ET-1 levels (18.9+/-6.8 pg/mL) were higher than those of HS and RP patients (P<0.01).
CONCLUSION
The increase of plasma ET-1 levels in RP patients suggests that ET-1 may play a role in the pathophysiology of the diseases involving retinal pigment epithelial cells and the retinal vascular system such as RP.
目的
本研究旨在调查患有视网膜色素变性（RP）和综合征性RP患者的血浆内皮素-1（ET-1）水平变化情况。
方法
从一组40例连续的RP患者中采集血样，并与35名健康受试者（HS）作为对照。我们进行了全面的眼科检查。研究组包括26例RP患者和14例综合征性RP患者。采用特异性放射免疫测定法重复测定血浆ET-1水平。
结果
HS组血浆ET-1水平为7.48±2.58 pg/mL。所有RP患者的血浆ET-1浓度平均值（16.2±5.6 pg/mL）显著高于HS组（P<0.01）。此外，综合征性RP患者的血浆ET-1水平（18.9±6.8 pg/mL）高于HS组和RP患者（P<0.01）。
结论
RP患者血浆ET-1水平升高表明ET-1可能在涉及视网膜色素上皮细胞和视网膜血管系统的疾病（如RP）的病理生理学中发挥作用。
Zotero 插件