Galobardes B, Davey Smith G, Jeffreys M, Kinra S, McCarron P
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom.
Am J Epidemiol. 2005 Jun 15;161(12):1094-101. doi: 10.1093/aje/kwi147.
Androgen level or androgen activity is implicated in several health outcomes, but its independent role remains controversial. This study investigated the association between history of acne in young adulthood, a marker of hormone activity, and cause-specific mortality in the Glasgow Alumni Cohort Study. Male students who attended Glasgow University between 1948 and 1968 and participated in voluntary health checks reported history of acne (n = 11,232). Vital status has been traced, and risk factors in adulthood are known for about 50% of the participants. Those with a history of acne were more often nonsmokers while university students and tended to be from a lower socioeconomic position. The two groups did not differ in other adolescent (height, body mass index, blood pressure, and number of siblings) or in most adult risk factors. Students who reported a history of acne had a lower risk of all-cause (hazard ratio = 0.89, 95% confidence interval (CI): 0.76, 1.04) and coronary heart disease (hazard ratio = 0.67, 95% CI: 0.48, 0.94) mortality but had some evidence of a higher risk of prostate cancer mortality (hazard ratio = 1.67, 95% CI: 0.79, 3.55). This study shows that androgen activity during adolescence may protect against coronary heart disease but confer a higher risk of prostate cancer mortality.
雄激素水平或雄激素活性与多种健康结果有关，但其独立作用仍存在争议。本研究在格拉斯哥校友队列研究中，调查了青年期痤疮病史（一种激素活性标志物）与特定病因死亡率之间的关联。1948年至1968年间就读于格拉斯哥大学并参加自愿健康检查的男学生报告了痤疮病史（n = 11232）。已追踪到他们的生命状态，约50%的参与者已知成年期的风险因素。有痤疮病史的人在大学生时期更常不吸烟，且往往来自社会经济地位较低的阶层。两组在其他青少年因素（身高、体重指数、血压和兄弟姐妹数量）或大多数成年风险因素方面没有差异。报告有痤疮病史的学生全因死亡风险较低（风险比=0.89，95%置信区间（CI）：0.76，1.04）和冠心病死亡风险较低（风险比=0.67，95%CI：0.48，0.94），但有证据表明前列腺癌死亡风险较高（风险比=1.67，95%CI：0.79，3.55）。这项研究表明，青春期的雄激素活性可能预防冠心病，但会增加前列腺癌死亡风险。
