Mowatt Lizette, Matthews Tim, Anderson Ioanne
Sandwell and West Birmingham NHS Trust, Birmingham and Midland Eye Center, Birmingham, England.
J Neuroophthalmol. 2005 Jun;25(2):113-5. doi: 10.1097/01.wno.0000165104.01237.3f.
A 68-year-old woman with chronic lymphocytic leukemia (CLL) had acute optic neuropathy associated with cerebrospinal fluid evidence of meningeal spread of CLL. There was no evidence of a hematologic relapse. After undergoing four weekly doses of intrathecal methotrexate, vision improved dramatically and spinal fluid became normal. Four years later, she has near normal vision in the affected eye and remains in hematologic remission. This is the first reported case of successful treatment of optic neuropathy in CLL with intrathecal methotrexate alone.
一名68岁的慢性淋巴细胞白血病（CLL）女性患者出现急性视神经病变，脑脊液检查显示有CLL脑膜播散的证据。没有血液学复发的迹象。在接受了四周每周一次的鞘内注射甲氨蝶呤治疗后，视力显著改善，脑脊液恢复正常。四年后，她患眼的视力接近正常，并且仍处于血液学缓解状态。这是首例单独使用鞘内注射甲氨蝶呤成功治疗CLL相关性视神经病变的报道病例。
