Kuno Shin-Ichi
Department of Clinical Study Management, Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, 1-5-4 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Clinical Genome Informatics Center, Kobe University Graduate School of Medicine, Kobe, Japan.
J Hum Genet. 2005;50(6):315-316. doi: 10.1007/s10038-005-0256-6. Epub 2005 Jun 4.
Linkage disequilibrium is the association between alleles in the allele distributions across linked loci and is intermediate in character between the dependence and the independence of allele distribution. This ambivalence makes linkage disequilibrium difficult to understand and to treat mathematically. To overcome this difficulty, an attempt was made to divide linkage disequilibrium between absolute linkage disequilibrium, which is a complete dependence of allele distribution, and linkage equilibrium, which is a complete independence. A matrix description of linkage disequilibrium showed that (1) linkage disequilibrium is divided between absolute linkage disequilibrium and linkage equilibrium, (2) a linkage disequilibrium state is characterized by the allele frequency in the first locus p, the relative content of absolute linkage disequilibrium d and the linkage equilibrium variable c, and (3) r is the geometric mean of both orientation's d. Division of linkage disequilibrium may make linkage disequilibrium straightforward to understand and to treat mathematically.
连锁不平衡是指在连锁基因座的等位基因分布中，等位基因之间的关联，其性质介于等位基因分布的依赖性和独立性之间。这种矛盾性使得连锁不平衡难以理解且难以用数学方法处理。为克服这一困难，人们尝试将连锁不平衡分为绝对连锁不平衡（即等位基因分布的完全依赖性）和连锁平衡（即完全独立性）。连锁不平衡的矩阵描述表明：（1）连锁不平衡分为绝对连锁不平衡和连锁平衡；（2）连锁不平衡状态由第一个基因座的等位基因频率p、绝对连锁不平衡的相对含量d和连锁平衡变量c来表征；（3）r是两个方向的d的几何平均值。对连锁不平衡进行划分可能会使连锁不平衡易于理解且便于用数学方法处理。
