婴儿百日咳的严重性：范围综述。
Severe pertussis in infants: a scoping review.
机构信息
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
出版信息
Ann Med. 2024 Dec;56(1):2352606. doi: 10.1080/07853890.2024.2352606. Epub 2024 May 10.
BACKGROUND
Pertussis (Whooping Cough) is a respiratory infection caused by . Pertussis usually occurs in childhood; severe infections are most common in infants. It can be fatal with severe complications such as pulmonary hypertension, heart failure, and encephalitis.
OBJECTIVES
We sought to synthesize the existing literature on severe pertussis in infants and inform further study.
METHODS
A scoping review was performed based on the methodological framework developed by Arksey & O'Malley. Search in Pubmed and Embase databases, with no restrictions on the language and date of publication.
RESULTS
Of the 1299 articles retrieved, 64 were finally included. The selected articles were published between 1979 and 2022, with 90.6% (58/64) of the studies in the last two decades. The studies covered epidemiology, pathology, clinical characteristics, risk factors, treatments, and burden of disease.
CONCLUSION
The literature reviewed suggests that studies on severe pertussis in infants covered a variety of clinical concerns. However, these studies were observational, and experimental studies are needed to provide high-quality evidence.
背景
百日咳（哮咳）是一种由 引起的呼吸道感染。百日咳通常发生在儿童时期；严重感染在婴儿中最为常见。它可能导致严重并发症，如肺动脉高压、心力衰竭和脑炎，从而危及生命。
目的
我们旨在综合现有的关于婴儿严重百日咳的文献，并为进一步的研究提供信息。
方法
根据 Arksey 和 O'Malley 制定的方法框架进行范围综述。在 Pubmed 和 Embase 数据库中进行搜索，不限制语言和出版日期。
结果
在检索到的 1299 篇文章中，最终有 64 篇被纳入。所选文章发表于 1979 年至 2022 年之间，其中 90.6%（58/64）的研究是在过去二十年进行的。这些研究涵盖了流行病学、病理学、临床特征、危险因素、治疗和疾病负担。
结论
综述的文献表明，关于婴儿严重百日咳的研究涵盖了各种临床关注点。然而，这些研究都是观察性的，需要进行实验研究以提供高质量的证据。
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