[乙型肝炎病毒所致慢性肝炎与肝细胞癌之间的临床及分子关联]
[Clinical and molecular correlation between chronic hepatitis and hepatocellular carcinoma induced by hepatitis B virus].
作者信息
Shapiro I Ia, Shabrov A V, Karev V E, Leenman E E, Kvetnoĭ I M, Tsinzerling V A, Sologub T V
出版信息
Arkh Patol. 2005 Mar-Apr;67(2):6-10.
PMID:15938110
Abstract
The role of X-gene of hepatitis B virus (HBV), telomerase gene, structural HBV proteins is considered. Both factors of the virus and those of the host are involved in hepatocarcinogenesis. The duration of chronic B hepatitis may influence mitogenic and mutagenic conditions for accumulation of occasional genetic and chromosomal damage and result in hepatocarcinoma development.
摘要
本文探讨了乙型肝炎病毒（HBV）的X基因、端粒酶基因及HBV结构蛋白的作用。病毒因素和宿主因素均参与肝癌的发生。慢性乙型肝炎的病程可能影响有丝分裂和诱变条件，导致偶然的基因和染色体损伤积累，进而引发肝癌。
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