Vershinina A M, Gapon L I, Veber E E, Popova S N, Pliusnin A V
Ter Arkh. 2005;77(4):55-8.
To study effects of fosinopril on a 24-h profile of blood pressure (BP) in hypertensive patients with obesity and hypercholesterolemia.
A randomized comparative trial enrolled 96 patients aged 30-50 years with arterial hypertension (AH) of the first and second degree. The patients were randomized into 2 groups by age, gender, AH duration, office AP, body mass index, cholesterol level. The patients of group 1 received fosinopril (monopril) in a single daily dose 10 mg with further rise to 20 mg. The patients of group 2 were given metoprolol twice a day in a dose 25 mg with further rise to 75 mg. Examination of the patients was made before the treatment and after 16 weeks of therapy with fosinopril and metoprolol.
A 16-week therapy with fosinopril resulted in lowering of office BP, mean day systolic, diastolic, pulse BP. The profile of SBP improved: the number of "dippers" with an adequate day profile of BP rose. Fosinopril significantly reduced left ventricular myocardial mass (LVMM) and myocardial mass index. Metoprolol had the same hypotensive action but had no effect on mean 24-h pulse and mean BP, LVMM, LVMM index.
Fosinopril is more effective than metoprolol in relation to a 24-h profile of BP and LVMM reduction.
研究福辛普利对肥胖合并高胆固醇血症高血压患者24小时血压（BP）变化的影响。
一项随机对照试验纳入了96例年龄在30 - 50岁的一、二级动脉高血压（AH）患者。根据年龄、性别、AH病程、诊室血压、体重指数、胆固醇水平将患者随机分为2组。第1组患者每日单次服用福辛普利（蒙诺）10 mg，随后增至20 mg。第2组患者每日服用美托洛尔2次，每次25 mg，随后增至75 mg。在使用福辛普利和美托洛尔治疗前及治疗16周后对患者进行检查。
福辛普利治疗16周可降低诊室血压、日间平均收缩压、舒张压、脉压。收缩压变化情况得到改善：血压日间变化正常的“勺型”患者数量增加。福辛普利显著降低左心室心肌质量（LVMM）和心肌质量指数。美托洛尔有相同的降压作用，但对24小时平均脉压、平均血压、LVMM、LVMM指数无影响。
在降低24小时血压和LVMM方面，福辛普利比美托洛尔更有效。
