Voruganti L P, Awad A G
McMaster University, Hamilton, ON, Canada.
Acta Psychiatr Scand Suppl. 2005(427):22-8. doi: 10.1111/j.1600-0447.2005.00541.x.
Neuroimaging studies on subjective responses to psychotropic drugs in humans were reviewed to examine progress in the field and identify gaps in knowledge.
An exhaustive search of computerized databases identified two categories of in vivo imaging studies: i) correlates of negative(dysphoric) subjective responses to neuroleptic use in schizophrenia, and ii) research on positive (euphoric) subjective responses, mostly from substance abuse population.
Research has been largely confined to neurochemical imaging of dopamine in the striatal complex, confirming earlier speculations that impaired or deficient dopaminergic function is associated with dysphoric responses, and enhanced activity is associated with euphoric or pleasurable responses. Cerebral blood flow, regional metabolic rate and glucose utilization studies provided preliminary clues to the putative neuroanatomical sites.
Neuroimaging techniques added credibility to the study of subjective responses; however, further studies are required to identify the underlying anatomical and neurochemical interactions in order to enhance their applied value.
回顾关于人类对精神药物主观反应的神经影像学研究，以审视该领域的进展并找出知识空白。
对计算机化数据库进行详尽搜索，确定了两类活体成像研究：i）精神分裂症患者使用抗精神病药物后负面（烦躁不安）主观反应的相关因素，以及ii）主要来自药物滥用人群的关于正面（欣快）主观反应的研究。
研究主要局限于纹状体复合体中多巴胺的神经化学成像，证实了早期的推测，即多巴胺能功能受损或不足与烦躁不安反应相关，而活性增强与欣快或愉悦反应相关。脑血流量、区域代谢率和葡萄糖利用研究为假定的神经解剖部位提供了初步线索。
神经影像学技术为研究主观反应增添了可信度；然而，需要进一步研究以确定潜在的解剖学和神经化学相互作用，以提高其应用价值。
