Kristensen Torsten Nygaard, Sørensen Peter, Kruhøffer Mogens, Pedersen Kamilla Sofie, Loeschcke Volker
Aarhus Centre for Environmental Stress Research, Department of Ecology and Genetics, University of Aarhus, Denmark.
Genetics. 2005 Sep;171(1):157-67. doi: 10.1534/genetics.104.039610. Epub 2005 Jun 8.
The deleterious consequences of inbreeding, especially in the form of inbreeding depression, are well known. However, little is known about how inbreeding affects genome-wide gene expression. Here, we show that inbreeding changes transcription levels for a number of genes. Gene expression profiles of Drosophila melanogaster lines inbred to F approximately = 0.67 at different rates changed relative to those of noninbred lines, but the rate of inbreeding did not significantly affect gene expression patterns. Genes being differentially expressed with inbreeding are disproportionately involved in metabolism and stress responses, suggesting that inbreeding acts like an environmental stress factor.
近亲繁殖的有害后果，尤其是近亲繁殖衰退的形式，是众所周知的。然而，关于近亲繁殖如何影响全基因组基因表达却知之甚少。在这里，我们表明近亲繁殖会改变许多基因的转录水平。以不同速率近亲繁殖至F约 = 0.67的黑腹果蝇品系的基因表达谱相对于非近亲繁殖品系发生了变化，但近亲繁殖速率并未显著影响基因表达模式。因近亲繁殖而差异表达的基因在代谢和应激反应中所占比例过高，这表明近亲繁殖的作用类似于环境应激因素。
