Malecha M J, Rubin R
Department of Pathology and Cell Biology, Thomas Jefferson University Hospital, Philadelphia.
Pathol Res Pract. 1992 Feb;188(1-2):145-7. doi: 10.1016/S0344-0338(11)81171-4.
Aneurysms of both common carotid arteries were seen in a patient with neurofibromatosis. Histologic examination of the involved arteries demonstrated a dense proliferation of spindle cells within the arterial walls accompanied by medial cystic degeneration and disruption of the tunica elastica. These changes were also observed in adjacent, grossly uninvolved segments of the blood vessels. Immunohistochemical analysis of the proliferating cells was positive with antibodies against desmin and muscle-specific actin. The findings demonstrate and confirm the smooth muscle origin of the aberrant proliferated cell population in arteries in a patient with von Recklinghausen's neurofibromatosis.
在一名患有神经纤维瘤病的患者中发现双侧颈总动脉动脉瘤。对受累动脉进行组织学检查，结果显示动脉壁内梭形细胞密集增殖，伴有中膜囊性变性和弹性膜破坏。在相邻的、大体上未受累的血管段也观察到了这些变化。对增殖细胞进行免疫组织化学分析，结果显示抗结蛋白抗体和肌肉特异性肌动蛋白抗体呈阳性。这些发现证实了冯·雷克林豪森神经纤维瘤病患者动脉中异常增殖细胞群的平滑肌起源。
