Haba S, Nisonoff A
Rosenstiel Research Center, Brandeis University, Waltham, MA 02254.
Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):5185-7. doi: 10.1073/pnas.89.11.5185.
We have shown previously that normal mice become tolerant to endogenous IgE when they are approximately 2 weeks old and that this corresponds closely with the initial appearance of IgE in serum. Tolerance evidently is restricted to T cells, since B cells responsive to IgE are present in neonatal and adult mice. The present report shows that IgE-secreting cells can be detected in the thymus between days 7 and 11 after birth and that the onset of tolerance to IgE occurs at the age of 11 days. Similar results were obtained in A/J and (BALB/c x A/J)F1 mice. This suggests that tolerance is induced in the thymus, probably by cells bearing peptide fragments of IgE. The order of appearance of IgE-secreting cells is thymus, spleen, and mesenteric lymph nodes.
我们之前已经表明，正常小鼠在大约2周龄时会对内源性IgE产生耐受，这与血清中IgE的最初出现密切相关。由于对IgE有反应的B细胞存在于新生小鼠和成年小鼠中，所以耐受性显然仅限于T细胞。本报告显示，出生后7至11天之间可在胸腺中检测到分泌IgE的细胞，并且对IgE的耐受性在11日龄时开始出现。在A/J和（BALB/c×A/J）F1小鼠中也获得了类似的结果。这表明耐受性是在胸腺中诱导产生的，可能是由携带IgE肽片段的细胞诱导的。分泌IgE细胞出现的顺序是胸腺、脾脏和肠系膜淋巴结。
