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2
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本文引用的文献

1
A clonal analysis of the IgE response and its implications with regard to isotope commitment.IgE 应答的克隆分析及其与同种型定向的关系
J Exp Med. 1981 Apr 1;153(4):783-92. doi: 10.1084/jem.153.4.783.
2
Recent studies on the regulation of IgE antibody synthesis in experimental animals and man.近期关于实验动物和人类中IgE抗体合成调控的研究。
Immunology. 1980 Sep;41(1):1-24.
3
A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells.一种用于计数特异性抗体分泌细胞的固相免疫酶技术。
J Immunol Methods. 1983 Feb 25;57(1-3):301-9. doi: 10.1016/0022-1759(83)90091-1.
4
Patterns of lymphatic drainage in the adult laboratory rat.成年实验大鼠的淋巴引流模式。
J Anat. 1971 Sep;109(Pt 3):369-83.
5
Communications. Heterologous adoptive cutaneous anaphylaxis: a method for detecting reaginic antibody formation by cells of the mouse.通讯。异种适应性皮肤过敏反应：一种检测小鼠细胞中反应素抗体形成的方法。
J Immunol. 1973 Aug;111(2):638-40.
6
Hapten-specific IgE antibody responses in mice. I. Secondary IgE responses in irradiated recipients of syngeneic primed spleen cells.小鼠对半抗原特异性的IgE抗体反应。I. 同基因致敏脾细胞照射受体中的二次IgE反应。
J Exp Med. 1973 Jul 1;138(1):306-11. doi: 10.1084/jem.138.1.306.
7
Regulation of homocytotropic antibody formation in the rat. 3. Effect of thymectomy and splenectomy.大鼠同种细胞嗜性抗体形成的调节。3. 胸腺切除和脾切除的影响。
J Immunol. 1971 Apr;106(4):1019-25.
8
Distribution of gamma E-forming cells in lymphoid tissues of the human and monkey.人类和猴子淋巴组织中γE形成细胞的分布。
J Immunol. 1970 Feb;104(2):377-87.
9
Hapten-specific IgE antibody responses in mice. IV. Evidence for distinctive sensitivities of IgE and IgG B lymphocytes to the regulatory influence of T cells.小鼠对半抗原特异性的IgE抗体反应。IV. IgE和IgG B淋巴细胞对T细胞调节影响的独特敏感性的证据。
J Immunol. 1974 Sep;113(3):974-83.
10
Immunoglobulin E (IgE) and IgE-containing cells in human gastrointestinal fluids and tissues.人胃肠液和组织中的免疫球蛋白E（IgE）及含IgE的细胞。
Clin Exp Immunol. 1975 May;20(2):227-37.

大鼠初次抗体应答过程中抗原特异性分泌IgE细胞的动力学及分布

Kinetics and distribution of antigen-specific IgE-secreting cells during the primary antibody response in the rat.

作者信息

Sedgwick J D, Holt P G

出版信息

J Exp Med. 1983 Jun 1;157(6):2178-83. doi: 10.1084/jem.157.6.2178.

DOI:10.1084/jem.157.6.2178
PMID:6189957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187046/
Abstract

A new assay system is described for the enumeration of antigen-specific IgE immunoglobulin-secreting cells (ISC) based on an enzyme-linked immunoabsorbent assay. Using this technique to monitor the organ distribution of OVA-specific ISC after primary immunization of rats, approximately 12,000 specific IgE ISC were detected at the peak of the response in the draining lymph nodes compared with 117,000 IgG ISC; the splenic anti-OVA response was restricted to the IgM class. Using plates precoated with anti-rat IgE instead of antigen, total IgE ISC were enumerated in normal and helminth-parasitized rats. The assay system detected up to 5 X 10(5) IgE ISC in mesenteric lymph nodes from parasitized animals compared with less than 50 in controls.

摘要

描述了一种基于酶联免疫吸附测定法来计数抗原特异性IgE免疫球蛋白分泌细胞（ISC）的新检测系统。使用该技术监测大鼠初次免疫后OVA特异性ISC的器官分布，在引流淋巴结反应高峰期检测到约12,000个特异性IgE ISC，而IgG ISC为117,000个；脾脏抗OVA反应仅限于IgM类。使用预包被抗大鼠IgE而非抗原的平板，对正常和感染蠕虫的大鼠中的总IgE ISC进行计数。该检测系统在感染动物的肠系膜淋巴结中检测到多达5×10⁵个IgE ISC，而对照组中少于50个。