Northcott Ellen, Connolly Anne M, Berroya Anna, Sabaz Mark, McIntyre Jenny, Christie Jane, Taylor Alan, Batchelor Jennifer, Bleasel Andrew F, Lawson John A, Bye Ann M E
School of Women's and Children's Health, University of NSW, Australia.
Epilepsia. 2005 Jun;46(6):924-30. doi: 10.1111/j.1528-1167.2005.62304.x.
Benign rolandic epilepsy (BRE) has an excellent prognosis for seizures, but recent research has raised concerns using cognition as an outcome measure. Methodologic problems related to recruitment bias and assessment processes are evident in previous studies. With well-defined criteria for inclusion and comprehensive assessment, the aim of this study was to define the cognitive profile of children with BRE and to assess the effect of interictal EEG activity.
Patients (n=42) were recruited from six EEG laboratories. The EEG features analyzed were spike frequency, trains, and laterality. Comprehensive neuropsychological and language assessments were conducted. Group means on cognitive measures were compared with normative means. Tests were correlated with EEG features.
The study demonstrated that children with BRE have normal intelligence and language ability. However, a specific pattern of difficulties in memory and phonologic awareness was found. Furthermore, a large proportion of children had disproportionate scores in these areas compared with intellectual and language ability. EEG features were minimally associated with cognitive difficulties, and no correlation was found with memory indices and tests of phonologic awareness.
Some children with BRE have specific difficulties in memory and phonologic processing skills, not explained by interictal activity. We recommend that pediatricians ask about academic performance specifically in areas of prereading, reading, spelling, and memory. If difficulties are suspected, assessment targeting phonologic awareness and memory are recommended, as they may not be reflected in overall intellectual and language ability. Difficulties in phonologic awareness affect literacy, and memory problems affect academic performance.
良性罗兰区癫痫（BRE）的癫痫发作预后良好，但最近的研究引发了对将认知作为结局指标的担忧。先前研究中与招募偏倚和评估过程相关的方法学问题很明显。本研究旨在通过明确的纳入标准和全面评估，确定BRE患儿的认知特征，并评估发作间期脑电图活动的影响。
从六个脑电图实验室招募患者（n = 42）。分析的脑电图特征包括棘波频率、序列和偏侧性。进行了全面的神经心理学和语言评估。将认知测量的组均值与常模均值进行比较。测试与脑电图特征相关。
研究表明，BRE患儿智力和语言能力正常。然而，发现了记忆和语音意识方面的特定困难模式。此外，与智力和语言能力相比，很大一部分儿童在这些领域的得分不成比例。脑电图特征与认知困难的关联最小，未发现与记忆指标和语音意识测试相关。
一些BRE患儿在记忆和语音处理技能方面存在特定困难，发作间期活动无法解释这些困难。我们建议儿科医生特别询问患儿在预读、阅读、拼写和记忆等方面的学业表现。如果怀疑有困难，建议针对语音意识和记忆进行评估，因为这些困难可能不会在整体智力和语言能力中体现出来。语音意识方面的困难会影响读写能力，记忆问题会影响学业成绩。
