Christensen Jakob, Kjeldsen Marianne Juel, Andersen Henning, Friis Mogens Laue, Sidenius Per
Department of Clinical Pharmacology, University of Aarhus, Aarhus, Denmark.
Epilepsia. 2005 Jun;46(6):956-60. doi: 10.1111/j.1528-1167.2005.51204.x.
The aim of this study was to look at gender differences in unselected populations of patients with epilepsy classified according to the 1989 International League Against Epilepsy (ILAE) criteria.
Data were obtained from two sources: (a) the EpiBase database at the outpatient clinic at the Department of Neurology, Aarhus University Hospital, Denmark, confined to adults with epilepsy (n=2,170), and (b) the Danish Twin Registry (n=318).
In localization-related epilepsy, no overall gender difference was found in either the EpiBase population (n=1,511; w=750 (50%), m=761 (50%); p=0.80) or in the twin population (n=172; w=86 (50%), m=86 (50%); p=1.00). However, in the EpiBase population, localization-related symptomatic epilepsies were more frequent in men (n=939; w=426 (45%), m=513 (55%); p=0.005); and cryptogenic localization-related epilepsies were more frequent in women (n=572; w=324 (57%), m=248 (43%); p=0.002). In generalized epilepsy, more women than men were diagnosed in both populations [EpiBase: n=480, w=280 (58%), m=200 (42%); p<0.001; twin population: n=105, w=63 (60%), m=42 (40%); p=0.05]. The difference was confined to idiopathic generalized epilepsy [EpiBase: n=437, w=259 (59%), m=178 (41%); p<0.001; twin population: n=94, w=60 (64%), m=34 (36%); p=0.01].
More women than men were diagnosed with idiopathic generalized epilepsy in two epilepsy populations. Overall, no gender difference was found in localization-related epilepsy, but localization-related symptomatic epilepsies were more frequent in men, and cryptogenic localization-related epilepsies were more frequent in women The results suggest a gender susceptibility to the development of specific epilepsy subtypes.
本研究旨在观察根据1989年国际抗癫痫联盟（ILAE）标准分类的未经选择的癫痫患者群体中的性别差异。
数据来自两个来源：（a）丹麦奥胡斯大学医院神经内科门诊的EpiBase数据库，限于成年癫痫患者（n = 2170），以及（b）丹麦双胞胎登记处（n = 318）。
在局灶性癫痫中，EpiBase人群（n = 1511；女性= 750（50%），男性= 761（50%）；p = 0.80）和双胞胎人群（n = 172；女性= 86（50%），男性= 86（50%）；p = 1.00）中均未发现总体性别差异。然而，在EpiBase人群中，局灶性症状性癫痫在男性中更常见（n = 939；女性= 426（45%），男性= 513（55%）；p = 0.005）；而隐源性局灶性癫痫在女性中更常见（n = 572；女性= 324（57%），男性= 248（43%）；p = 0.002）。在全身性癫痫中，两个群体中诊断出的女性均多于男性[EpiBase：n = 480，女性= 280（58%），男性= 200（42%）；p < 0.001；双胞胎人群：n = 105，女性= 63（60%），男性= 42（40%）；p = 0.05]。这种差异仅限于特发性全身性癫痫[EpiBase：n = 437，女性= 259（59%），男性= 178（41%）；p < 0.001；双胞胎人群：n = 94，女性= 60（64%），男性= 34（36%）；p = 0.01]。
在两个癫痫患者群体中，诊断为特发性全身性癫痫的女性多于男性。总体而言，在局灶性癫痫中未发现性别差异，但局灶性症状性癫痫在男性中更常见，而隐源性局灶性癫痫在女性中更常见。结果表明特定癫痫亚型的发生存在性别易感性。
