谷胱甘肽过氧化物酶1（GPX Pro198Leu）和8-氧鸟嘌呤DNA糖基化酶1（OGG1 Ser326Cys）基因多态性与结肠直肠腺瘤和结肠直肠癌发生风险
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
作者信息
Hansen Rikke, Saebø Mona, Skjelbred Camilla Furu, Nexø Bjørn Andersen, Hagen Per Christian, Bock Günther, Bowitz Lothe Inger Marie, Johnson Egil, Aase Steinar, Hansteen Inger-Lise, Vogel Ulla, Kure Elin H
机构信息
National Institute of Occupational Health, Copenhagen, Denmark.
出版信息
Cancer Lett. 2005 Nov 8;229(1):85-91. doi: 10.1016/j.canlet.2005.04.019.
Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma or adenomas. We studied 166 cases with adenocarcinoma, 974 with adenomas and 397 controls recruited from the Norwegian cohort NORCCAP. No associations were found between the polymorphism GPX Pro198Leu and risk of colorectal adenomas or carcinomas. Carriers of the variant allele OGG1 Ser326Cys polymorphism had a lowered risk of colorectal cancer, OR=0.56 (95% confidence interval 0.33-0.95), while no association were found with risk of adenomas. This indicates that a low repair capacity of oxidative DNA damage may not be a risk factor for development of colorectal adenomas or carcinoma.
关于结直肠癌的遗传风险因素，人们知之甚少。我们评估了参与氧化应激DNA修复的两个基因GPX和OGG1的多态性与结直肠癌或腺瘤风险之间的关联。我们研究了从挪威队列NORCCAP招募的166例腺癌患者、974例腺瘤患者和397例对照。未发现GPX Pro198Leu多态性与结直肠腺瘤或癌风险之间存在关联。OGG1 Ser326Cys多态性变异等位基因携带者患结直肠癌的风险降低，OR=0.56（95%置信区间0.33-0.95），而未发现与腺瘤风险存在关联。这表明氧化DNA损伤的低修复能力可能不是结直肠腺瘤或癌发生的风险因素。
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