Weisse C S
Department of Psychology, Union College, Schenectady, New York 12308.
Psychol Bull. 1992 May;111(3):475-89. doi: 10.1037/0033-2909.111.3.475.
Recent evidence suggests that there is a relationship between depression and immunity. On the basis of these studies, it has been argued that depressed mood may increase susceptibility to disease by means of aberrations occurring within the immune system. Empirical research investigating the relationship between depression and immunity is reviewed here. Studies examining both clinical and nonclinical manifestations of depression are discussed and evaluated. This review reveals that indexes of immunocompetence are lower among people exhibiting depressive symptomology and suggests that immune alterations may be more related to dysphoric mood than to specific situations or events. Alternative hypotheses accounting for links between depressed affect and altered immune states are provided, and suggestions for future research are offered.
近期证据表明，抑郁症与免疫力之间存在关联。基于这些研究，有人认为抑郁情绪可能通过免疫系统内出现的异常情况增加患病易感性。本文综述了调查抑郁症与免疫力之间关系的实证研究。对考察抑郁症临床和非临床表现的研究进行了讨论和评估。这篇综述表明，在表现出抑郁症状的人群中，免疫能力指标较低，并表明免疫改变可能与烦躁情绪的关系比与特定情况或事件的关系更大。文中还提供了解释抑郁情绪与免疫状态改变之间联系的其他假说，并给出了对未来研究的建议。
