文献综述：将心理神经免疫学整合到儿科慢性病干预中。
Review of the literature: integrating psychoneuroimmunology into pediatric chronic illness interventions.
作者信息
Nassau Jack H, Tien Karen, Fritz Gregory K
机构信息
Bradley Hasbro Children's Research Center, CORO Center West - Suite 204, 1 Hoppin Street, Providence, RI 02903, USA.
出版信息
J Pediatr Psychol. 2008 Mar;33(2):195-207. doi: 10.1093/jpepsy/jsm076. Epub 2007 Sep 10.
OBJECTIVE
Provide an orientation to psychoneuroimmunology, a rationale for including assessments of immune function in intervention studies of pediatric chronic illness, review the current literature, and provide recommendations for future research.
METHODS
Using electronic searches and previous reviews, selected and reviewed published studies in which immunological changes related to psychological interventions were assessed in pediatric samples.
RESULTS
Eight studies were identified and included in the review. These utilized a range of interventions (e.g., disclosure and hypnosis) and included a variety of pediatric samples (e.g., those with asthma, HIV infection, or lupus).
CONCLUSIONS
Results suggest that psychological intervention can influence immune function in pediatric samples. Recommendations for advancing our knowledge by studying populations for whom the immune system plays an active role in disease pathophysiology, measuring disease-relevant immune mediators, studying pediatric patients under times of stress, and focusing on interventions aimed at altering the stress system are provided.
目的
介绍心理神经免疫学，阐述在儿科慢性病干预研究中纳入免疫功能评估的基本原理，回顾当前文献，并为未来研究提供建议。
方法
通过电子检索和以往综述，筛选并回顾已发表的研究，这些研究评估了儿科样本中与心理干预相关的免疫变化。
结果
共识别出八项研究并纳入本综述。这些研究采用了一系列干预措施（如信息披露和催眠），纳入了多种儿科样本（如患有哮喘、艾滋病毒感染或狼疮的儿童）。
结论
结果表明心理干预可影响儿科样本的免疫功能。提出了一些建议，包括研究免疫系统在疾病病理生理学中起积极作用的人群、测量与疾病相关的免疫介质、研究处于压力时期的儿科患者以及专注于旨在改变应激系统的干预措施，以增进我们的认识。
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