通过大规模粪便潜血检测计划检测结直肠癌。
Detecting colorectal cancer with a large scale fecal occult blood testing program.
作者信息
Gregorio D I, Lolachi P, Hansen H
机构信息
University of Connecticut, School of Medicine, Department of Community Medicine and Health Care, Farmington.
出版信息
Public Health Rep. 1992 May-Jun;107(3):331-5.
The researchers analyzed outcome data for 439 persons who had positive fecal occult blood tests in a 1984 statewide program for Connecticut residents. Among those with positive test results, colorectal cancer was diagnosed in 33 persons, 7.5 percent of the sample, during 3.5 years of follow-up. More than one-half of all cases found, 15 of 29 persons, or 52 percent, were diagnosed with in-situ or localized tumors, which are most likely to be treated successfully. The predictive value of a positive test varied according to the screened person's age and the number of positive tests obtained from that person. Among those 60 years or older, the positive predictive value of the screening test was 9 percent, compared to 3 percent for persons younger than 60 years. Having more than one positive test was associated with a positive predictive value of 12 percent, compared to 5 percent for one positive test. The findings support the use of fecal occult blood testing for early detection of colorectal cancer.
研究人员分析了1984年一项针对康涅狄格州居民的全州计划中439名粪便潜血试验呈阳性者的结果数据。在检测结果呈阳性的人群中，在3.5年的随访期间，有33人被诊断为结直肠癌，占样本的7.5%。所有确诊病例中，超过一半，即29人中的15人，也就是52%，被诊断为原位癌或局限性肿瘤，这类肿瘤最有可能得到成功治疗。检测呈阳性的预测价值因被筛查者的年龄以及该人获得的阳性检测次数而异。在60岁及以上的人群中，筛查试验的阳性预测值为9%，而60岁以下人群为3%。进行过一次以上阳性检测者的阳性预测值为12%，而一次阳性检测者为5%。这些发现支持使用粪便潜血试验来早期检测结直肠癌。
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