Fujiwara S, Sposto R, Ezaki H, Akiba S, Neriishi K, Kodama K, Hosoda Y, Shimaoka K
Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima City, Japan.
Radiat Res. 1992 Jun;130(3):372-8.
To determine the effect of exposure to atomic bomb radiation on the occurrence of hyperparathyroidism, the prevalence was determined among a population of 3,948 atomic bomb survivors and their controls in Hiroshima. The diagnosis of hyperparathyroidism was based upon histopathological findings or the presence of consistent hypercalcemia and elevated levels of serum parathyroid hormone. Primary hyperparathyroidism was diagnosed in 19 persons (3 males, 16 females). Females had approximately a threefold higher overall prevalence of hyperparathyroidism than males (P less than 0.05). The prevalence rates of hyperparathyroidism increased with radiation dose (chi2(1) = 12, P less than 0.001) after adjusting for sex and age at the time of the bombing. The estimated relative risk was 4.1 at 1 Gy (95% confidence limits 1.7 to 14). There was some evidence that the effect of radiation was greater for individuals who were younger at the time of the bombing. In conclusion, exposure to atomic bomb radiation affected the occurrence of hyperparathyroidism, suggesting that doses of radiation lower than those used in radiotherapy may also induce this disorder.
为确定暴露于原子弹辐射对甲状旁腺功能亢进症发生的影响，在广岛的3948名原子弹幸存者及其对照人群中测定了该病的患病率。甲状旁腺功能亢进症的诊断基于组织病理学检查结果或持续性高钙血症及血清甲状旁腺激素水平升高。确诊原发性甲状旁腺功能亢进症的有19人（3名男性，16名女性）。女性甲状旁腺功能亢进症的总体患病率约为男性的三倍（P<0.05）。在对爆炸时的性别和年龄进行校正后，甲状旁腺功能亢进症的患病率随辐射剂量增加而升高（χ2(1)=12，P<0.001）。估计在1戈瑞时相对风险为4.1（95%置信区间1.7至14）。有证据表明，爆炸时年龄较小的个体受辐射影响更大。总之，暴露于原子弹辐射会影响甲状旁腺功能亢进症的发生，这表明低于放射治疗所用剂量的辐射也可能诱发该疾病。
