Chang Ellen T, Hedelin Maria, Adami Hans-Olov, Grönberg Henrik, Bälter Katarina A
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Cancer Causes Control. 2005 Apr;16(3):275-84. doi: 10.1007/s10552-004-3364-2.
It is unknown whether the association of alcohol consumption with prostate cancer risk varies between localized and advanced cases, or between sporadic and familial cases.
We assessed recent alcohol drinking in a population-based case--control study of Swedish men, including 1499 cases and 1130 controls. Drinking status and average volume, frequency, and type of alcohol consumed were evaluated. Unconditional logistic regression was performed to estimate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for associations between alcohol consumption and prostate cancer risk.
Prostate cancer cases were more likely than controls to be current or former, rather than never, drinkers. However, there was no association between recent total alcohol, beer, wine, and liquor consumption and risk of overall prostate cancer, nor advanced, sporadic, or familial prostate cancer. The OR for risk of overall disease among men who drank more than 135 g of total alcohol per week versus non-drinkers was 1.2 (95% CI: 0.9, 1.5), p(trend)=0.12. There was a marginal positive association between alcohol intake and risk of localized disease.
We detected no association between recent alcohol consumption and risk of advanced, sporadic, or familial prostate cancer, and a borderline positive association with localized disease.
饮酒与前列腺癌风险之间的关联在局限性和晚期病例之间，或散发性和家族性病例之间是否存在差异尚不清楚。
在一项基于人群的瑞典男性病例对照研究中，我们评估了近期饮酒情况，该研究包括1499例病例和1130名对照。评估了饮酒状态以及饮酒的平均量、频率和类型。采用无条件逻辑回归来估计饮酒与前列腺癌风险之间关联的比值比（OR）及相应的95%置信区间（CI）。
前列腺癌病例比对照更有可能是当前或既往饮酒者，而非从不饮酒者。然而，近期总酒精摄入量、啤酒、葡萄酒和烈酒摄入量与总体前列腺癌风险、晚期、散发性或家族性前列腺癌风险之间均无关联。每周饮用超过135克总酒精的男性与不饮酒者相比，总体疾病风险的OR为1.2（95%CI：0.9，1.5），p（趋势）=0.12。酒精摄入量与局限性疾病风险之间存在微弱的正相关。
我们未发现近期饮酒与晚期、散发性或家族性前列腺癌风险之间存在关联，与局限性疾病存在临界正相关。
