Murray A K, Herrick A L, Moore T L, King T A, Griffiths C E M
Laser Photonics Group, Department of Physics and Astronomy, University of Manchester, Manchester M13 9PL, UK.
Br J Dermatol. 2005 Jun;152(6):1182-6. doi: 10.1111/j.1365-2133.2005.06479.x.
Increased blood flow occurs in plaques of psoriasis, and an increase in blood flow has been shown to occur in uninvolved skin adjacent to the active edge.
In order to gain more insight into the pathophysiology of the active edges of plaques of psoriasis, we investigated different components of the microcirculation in the lesional and nonlesional skin of patients with psoriasis, using dual wavelength laser Doppler imaging (LDI).
The cutaneous blood flow in 23 plaques on the forearms of 20 patients with chronic plaque psoriasis was recorded using dual wavelength LDI. Perfusion was determined within the plaque (P), in uninvolved skin adjacent to the plaque (A) and in nonadjacent skin (U).
Perfusion in plaques was increased as imaged by either 633 nm (red wavelength) or 532 nm (green wavelength) compared with both adjacent and nonadjacent uninvolved skin: median (interquartile range) P/A(RED) = 3.7 (2.5-4.9), P/A(GREEN) = 1.3 (1.2-1.6), P/U(RED) = 4.2 (2.7-6.1), P/U(GREEN) = 1.5 (1.3-1.9).
Vascular perfusion is increased within plaques of psoriasis compared with adjacent and nonadjacent uninvolved skin. The results suggest an area of increased perfusion in skin adjacent to plaques, when compared with nonadjacent skin, for both deeper (large) and superficial (small) vessels (imaged by 633 and 532 nm, respectively). We believe that this dual wavelength tool may be a suitable and useful way of assessing pathophysiology and treatment response in psoriasis.
银屑病斑块处血流增加，且已证实在活跃边缘附近的非病变皮肤中血流也会增加。
为了更深入了解银屑病斑块活跃边缘的病理生理学，我们使用双波长激光多普勒成像（LDI）研究了银屑病患者病变皮肤和非病变皮肤微循环的不同组成部分。
使用双波长LDI记录20例慢性斑块状银屑病患者前臂上23个斑块的皮肤血流。测定斑块内（P）、斑块相邻的非病变皮肤（A）和非相邻皮肤（U）的灌注情况。
与相邻和非相邻的非病变皮肤相比，无论是633nm（红色波长）还是532nm（绿色波长）成像，斑块内的灌注均增加：中位数（四分位间距）P/A（红色）=3.7（2.5 - 4.9），P/A（绿色）=1.3（1.2 - 1.6），P/U（红色）=4.2（2.7 - 6.1），P/U（绿色）=1.5（1.3 - 1.9）。
与相邻和非相邻的非病变皮肤相比，银屑病斑块内的血管灌注增加。结果表明，与非相邻皮肤相比，斑块附近皮肤中较深（大）和较浅（小）血管（分别由633nm和532nm成像）的灌注均增加。我们认为这种双波长工具可能是评估银屑病病理生理学和治疗反应的一种合适且有用的方法。
