Girardi Guillermina
Department of Medicine, Hospital for Special Surgery-Weill Medical College of Cornell University, New York, NY 10021, USA.
J Reprod Immunol. 2005 Jun;66(1):45-51. doi: 10.1016/j.jri.2005.01.006.
Interventions with heparin therapies have increased fetal survival in patients with antiphospholipid syndrome (APS). In this review, several physiological and pharmacological effects of heparin are described. These different mechanisms of action could explain the beneficial effects of heparin in the treatment of recurrent pregnancy loss in patients with APS. In addition to direct effects of heparin on the coagulation cascade, heparin might protect pregnancies by reducing the binding of antiphospholipid antibodies, reducing inflammation, facilitating implantation and or inhibiting complement activation.
肝素疗法干预提高了抗磷脂综合征（APS）患者的胎儿存活率。在本综述中，描述了肝素的几种生理和药理作用。这些不同的作用机制可以解释肝素在治疗APS患者复发性流产中的有益作用。除了肝素对凝血级联的直接作用外，肝素可能通过减少抗磷脂抗体的结合、减轻炎症、促进着床和/或抑制补体激活来保护妊娠。
