Department of Psychiatry at Fundacion Jimenez Diaz Hospital and Autonoma University, CIBERSAM, Madrid, Spain.
Schizophr Res. 2010 Feb;116(2-3):184-90. doi: 10.1016/j.schres.2009.11.006. Epub 2009 Nov 28.
Advanced parental age has been shown to increase offspring risk for a number of neuropsychiatric disorders including schizophrenia and Down's syndrome. Other psychiatric disorders have been less studied with respect to the effect of parental age on offspring risk. In this study we examine if advanced parental age increased risk for ICD-10 diagnoses. We hypothesized that advanced parental age would increase risk for offspring psychotic disorders and mental retardation but not other ICD-10 diagnoses. We examined follow-up data for 30,965 subjects treated in outpatient psychiatric facilities between 1980 and 2007. Subjects were younger than 18 years of age at their first outpatient visit. A comparison group was obtained from data on registered births in Spain from 1975. We compared parental age (maternal, paternal, combined) across diagnostic categories using ANOVA and logistic regression was used to estimate the risk of psychopathology in the offspring with advanced parental age (maternal, paternal, combined). Maternal and paternal ages were higher for subjects diagnosed with mental retardation. Risk for psychotic disorders showed a significant linear increase only with advancing maternal age, and not paternal age as is more often reported.
高龄父母已被证实会增加子女患多种神经精神疾病的风险，包括精神分裂症和唐氏综合征。高龄父母对子女患病风险的影响在其他精神疾病方面的研究则较少。本研究旨在探讨高龄父母是否会增加子女患国际疾病分类第 10 版（ICD-10）诊断的风险。我们假设高龄父母会增加子女患精神病和智力障碍的风险，但不会增加其他 ICD-10 诊断的风险。我们对 1980 年至 2007 年间在门诊精神病机构接受治疗的 30965 名患者的随访数据进行了检查。患者首次门诊就诊时年龄均小于 18 岁。对照组数据来源于西班牙 1975 年的注册出生数据。我们使用方差分析比较了不同诊断类别的父母年龄（母亲、父亲、双亲），并使用 logistic 回归来估计高龄父母（母亲、父亲、双亲）对子女患精神病理学的风险。智力障碍患者的母亲和父亲年龄均较高。仅随着母亲年龄的增加，患精神病的风险呈显著线性增加，而不是像通常报道的那样随着父亲年龄的增加而增加。
